Figure 3.
Fig. 3. a, comparison of the free RING finger domain of
EL5 with the E2-bound form of c-Cbl and the dimerization domain
of RAG1. The additional -helices at
the N and C termini of RAG1 are shown in yellow. b, surface
potential representations of these domains. Positively charged
areas are blue, and negatively charged areas are red. The
hydrophobic grooves in c-Cbl and EL5 are indicated by arrows.
The atomic coordinates for c-Cbl and RAG1 were downloaded from
the Protein Data Bank at Brookhaven National Laboratory
(accession numbers: 1FBV and 1RMD, respectively).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2003,
278,
15341-15348)
copyright 2003.
-helices at
the N and C termini of RAG1 are shown in yellow. b, surface
potential representations of these domains. Positively charged
areas are blue, and negatively charged areas are red. The
hydrophobic grooves in c-Cbl and EL5 are indicated by arrows.
The atomic coordinates for c-Cbl and RAG1 were downloaded from
the Protein Data Bank at Brookhaven National Laboratory
(accession numbers: 1FBV and 1RMD, respectively).