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Figure 3.
Fig 3. Stereoview of Topotecan binding. The Topotecan
interactions with protein side chains for the lactone (A, blue)
and carboxylate (B, gold) forms of the drug are depicted.
Hydrogen bonds (predicted by contact distance and geometry of
the refined atomic positions) are shown as solid blue lines, and
the calculated interatomic distances are indicated. Labels for
residues that result in resistance to CPT when mutated are
highlighted in yellow. The oxygen atoms of water molecules are
depicted as light blue spheres. Protein side chains are green,
and noncarbon atoms are colored red for oxygen, blue for
nitrogen, and magenta for phosphorus. The DNA and protein side
chains that do not interact with Topotecan have been omitted
from the figure.
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