Figure 3.
Figure 3 (A) RIBBONS diagram highlighting the position of E.coli
DnaA mutations mapped to the A.aeolicus DnaA model (blue
spheres). Identification and phenotype of mutations can be found
in Table II. The shaded oval (gray) marks the location of the
12
hinge region reported to play a role in cardiolipin-mediated
effects. (B) RIBBONS diagrams of DnaA domain IV and trp
repressor DNA-binding domain/DNA complex (Otwinowski et al.,
1988) highlighting the closely related HTH motif in gold. Highly
conserved residues in the basic loop and the DnaA signature
sequences are indicated by spheres. Residues determined by
mutagenesis to be critical for DNA binding in E.coli that map to
the HTH and the basic loop motifs are highlighted in red. (C)
RIBBONS model of the DnaA−DNA complex based on the trp
repressor/DNA complex. The positions of the signature sequence
motif and the basic loop are indicated.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2002,
21,
4763-4773)
copyright 2002.
12
hinge region reported to play a role in cardiolipin-mediated
effects. (B) RIBBONS diagrams of DnaA domain IV and trp
repressor DNA-binding domain/DNA complex (Otwinowski et al.,
1988) highlighting the closely related HTH motif in gold. Highly
conserved residues in the basic loop and the DnaA signature
sequences are indicated by spheres. Residues determined by
mutagenesis to be critical for DNA binding in E.coli that map to
the HTH and the basic loop motifs are highlighted in red. (C)
RIBBONS model of the DnaA−DNA complex based on the trp
repressor/DNA complex. The positions of the signature sequence
motif and the basic loop are indicated.