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Figure 3.
Figure 3. The molecular surface of EFEa with (a)
electrostatic potential distribution and (b) hydrophobicity
property. In (a), the regions with negative and positive charges
are shown in red and blue, respectively. The S1, S2 (Tyr99) and
S4 subsites are marked, as are the charged residues Asp60, Arg35
and Arg143 near the S1 pocket and residues Ser217A and Asn192 at
the south border of the S1 pocket. In (b), the hydrophobic
surface is shown in white, the polar surface in yellow, and the
charged surface in blue (positive) and red (negative). (c) The
EFEa active-site residue distribution. A sphere with 11 Å
radius was drawn centered at the S1 specificity pocket.
One-letter codes were used for the residues with the solvent
molecules drawn as red balls and labeled with green numerals.
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