Figure 3.
Fig. 3. Fine structure of the GPIb R-loop and
anionic region. a and b, the R-loop and -strands
from the concave face viewed from two orientations related by
90° rotation are shown. Key residues are labeled including
platelet-type von Willebrand disease mutations G233V and M239V
and the Bernard-Soulier syndrome mutation A156V. c, fine
structure of the GPIb anionic
region. Key residues in the anionic region (residues 269-279)
are indicated showing the interactions with the disulfide loop
and -turn repeat
motif from LRR8. The backbone of the anionic region is colored
red, the disulfide loop is colored dark green, and the LRR8 is
colored blue. Key hydrogen bonding/electrostatic interactions
are indicated as dotted blue lines.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2002,
277,
35657-35663)
copyright 2002.
R-loop and
anionic region. a and b, the R-loop and 
-strands
from the concave face viewed from two orientations related by
90° rotation are shown. Key residues are labeled including
platelet-type von Willebrand disease mutations G233V and M239V
and the Bernard-Soulier syndrome mutation A156V. c, fine
structure of the GPIb