Figure 3 - full size

 

Figure 3.
Fig. 3. Estradiol binds to human SHBG in an opposite orientation when compared with 3 ,17 Adiol. A, stereo image of the human SHBG steroid-binding site occupied by estradiol. B, superposition of the steroid-binding site in the 3 ,17 Adiol (in blue) and estradiol (in yellow) complexes, illustrating the differences in steroid orientation and coordination. Images were prepared with Molscript (34) and Raster3d (35).

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2002, 277, 32086-32093) copyright 2002.