Figure 3.
Fig. 3. Potential cis dimerization interface. (A) Comparison of
similar interfaces seen in the crystal structures of the
C-cadherin ectodomain (this work), and two structures of a
two-domain fragment from E-cadherin in space groups P2[1] (PDB
code 1FF5) and C2 (PDB code 1EDH). EC1 and EC2 domains are
shown. Primary regions of contact include the front sheet of
EC1 (strands C, D, and F), which interact with residues mainly
from the back sheet of EC2 (strands B, D, and E). (B) Detailed
stereo view of the cis-oriented interface. Residues that make
direct contact in the interface are labeled, and calcium ions
are shown as green spheres. Primes indicate the partner
molecule. The conserved residue Asp44 in the quasi- -helix
region is in close proximity to the EC2 to EC3 calcium-binding
region, although direct ligation of calcium ions is not
observed. Images were made with the program SETOR (35).
The above figure is reprinted
by permission from the AAAs:
Science
(2002,
296,
1308-1313)
copyright 2002.
sheet of
EC1 (strands C, D, and F), which interact with residues mainly
from the back sheet of EC2 (strands B, D, and E). (B) Detailed
stereo view of the cis-oriented interface. Residues that make
direct contact in the interface are labeled, and calcium ions
are shown as green spheres. Primes indicate the partner
molecule. The conserved residue Asp44 in the quasi-