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Figure 3.
Figure 3. Structures of the Active Sites of  epsilon,
Greek 186 and Other Exonuclease Domains(A and B) Low- and
high-pH structures, respectively, of the active site of epsilon,
Greek 186. The two Mn(II) ions, Mn[A] and Mn[B] are shown (in
orange) coordinated to the 5'-phosphate of TMP. The remainder of
the TMP molecules are omitted for clarity (but see Figure 4).
Coordinated-water molecules are represented by red spheres.(C-E)
Comparative structures of the 3'-5' exonuclease active sites of
exonuclease I (PDB code 1FXX) [41], DNA polymerase I (1KRP)
[51], and bacteriophage T4 DNA polymerase (1NOY) [7]. Structures
were aligned as in Figure 2, and diagrams were drawn using
RIBBONS [78].
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