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Figure 3.
Figure 3. A conformational change in the kinase is required for
the binding of diaryl urea inhibitors. a, Stereo view showing
the conformational change for the DFG motif. The DFG-in
conformation is shown with the carbon atoms in light blue, and
the DFG-out conformation is in gray. Also shown is the overlay
of the binding modes of compound 1 (green), the 3'-iodo analog
of SB 203580 (cyan)8 and ATP (purple). b, Molecular surface of
the p38 MAP kinase in the active site region in complex with
compound 1. For clarity, residues in the DFG motif are shown as
a stick model. The ATP molecule is shown for reference. c,
Stereo view showing the binding pocket (gray for carbon atoms)
for BIRB 796 (green). Also shown is compound 1 and the
conformation of Glu 71 (cyan) in that complex. Produced with
GRASP29.
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