|
Figure 3.
Figure 3. Structures of Murine NKD NK Cell Receptor-Ligand
ComplexesRibbon representations (top) and GRASP (Nicholls et
al., 1991) molecular surfaces (bottom) are shown for the
structures of (A) the muNKG2D–RAE-1β, (B) huNKG2D–MICA, and
(C) Ly49A-H-2D^d complexes. Ribbons of the ligands are colored
by domain: α1, yellow; α2, red; α3 (when present), green; and
β[2]-m (when present), cyan; ribbons of the receptors are
colored by chain: blue or purple. Molecular surfaces of the
platform domains are oriented such that the view is looking down
onto the NKG2D binding surface of RAE-1 and MICA. In (A), the
molecular surface of muNKG2D was included in an orientation
looking down onto the RAE-1 binding surface, as if the receptor
had been peeled away from the complex. Molecular surfaces are
colored by electrostatic potential, with positively charged
areas in blue and negatively charged areas in red. In (C), the
bound peptide in H-2D^d is shown in ball-and-stick
representation.
|
