|
Figure 3.
Fig. 3. Unique activation mechanism proposed based on the
crystal structures of BTK-KD and phospho-LCK. Panel A,
comparison of the superimposed BTK-KD (white backbones and
multiple color side chains in stick model) and the phospho-LCK
structures (gold backbones and red stick model side chains). The
black lines indicate hydrogen bonds. Panel B, we propose that
critical changes may occur when Arg-544 solely interacts with
phosphotyrosine 551 upon phosphorylation and Arg-544 releases
Glu-445, which subsequently takes part in ATP binding, which may
be a critical component of catalysis. N-lobe, N-terminal lobe;
C-lobe, C-terminal lobe.
|
