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Figure 3.
Figure 3. γ:γ Interfacial Nucleotide Binding Sites
Compared to the NSF Homolog p97(A) The nucleotide binding site
of p97 (left) (Zhang et al., 2000) (PDB code 1E32) is compared
to that of γ2 (at the γ1-γ2 interface, middle) and of γ3 (at
the γ2-γ3 interface, right). For the γ structures, Domains I
and II are colored, and Domain III is shown in gray. A schematic
representation of the Domain I–II units is shown below the
structures. ADP bound to p97 is shown at the active site of γ2
(middle) and γ3 (right) for reference. The arginine side chains
of the Sensor 1 region are shown in dark blue at each
interface.(B) The Sensor 1 region of γ1 is buried at the
γ1-γ2 interface. On the left, the γ1-γ2 pair of subunits is
shown, with the molecular surface of γ2 colored in gray,
highlighted in red where γ1 contacts the γ2 surface. γ1 is
shown as a green tube representing the backbone, with the Sensor
1 region colored magenta. γ2 is shown with the surface removed
on the right
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