Figure 3 - full size

Figure 3. Figure 3. Positions that Affect Affinity for Human FcRn Highlighted on the Structure of Human FcA single polypeptide chain from the structure of human Fc (coordinates obtained from Mark Ultsch, Genentech) is shown with side chains highlighting positions where substitutions result in reduced (red side chain) or enhanced (green side chain) affinity for human FcRn, based upon mutagenesis studies by Shields et al. (2001) (Table 4). Residues within the predicted interface with human FcRn (within 5 Å of an FcRn atom using a human FcRn/human Fc model generated from the rat FcRn/hdFc structure) are indicated by thick side chains and labels. Residues predicted to be outside of the interface are indicated by thin side chains and smaller labels

The above figure is reprinted by permission from Cell Press: Mol Cell (2001, 7, 867-877) copyright 2001.