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Figure 3.
Fig. 3. Molecular anatomy and shape complementarity of the site
II interface. (A) Amino acid contact residues within the site II
interface; gp130 (blue) is at the left and vIL-6 (purple) at the
right, and hydrogen bonds appear as red dotted lines. The
conserved gp130 Phe^169 and vIL-6 Trp18 are in the center of the
interface. (B and C) The site II vIL-6-gp130 interface is peeled
open, and the contact residues of one molecule are projected
onto the buried surface (red) of the interacting protein. Trp18
of vIL-6 (green) and Phe^169 of gp130 (blue) are used as anchor
points (arrows) to orient the reader between the two surfaces.
In (B), the gp130 contact residues (yellow) and binding-site
loops (blue) are shown as sticks projected onto the molecular
surface of vIL-6, where the buried portion is highlighted in
red. A deep canyon that receives the protruding gp130 elbow is
evident on the surface of vIL-6. The central Trp18 of vIL-6 is
highlighted on the red surface as a green patch. In (C), the
vIL-6 contact residues (yellow) and helices (pink) are drawn as
sticks projected onto the protruding molecular surface of gp130.
The Phe^169 of gp130 is drawn as a blue patch [see (38)].
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