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Figure 3.
Figure 3. Comparison of the
interactions of DLC8 with the Bim
peptide and the nNOS peptide.
Stereoview representations of (a)
the Bim peptide; and (b) the nNOS
peptide binding grooves of DLC8.
For clarity, only the regions of
DLC8 that are directly involved in
the binding are included in the
figure. In (a) and (b) the target pep-
tides are shown using explicit atom
representations in magenta. Amino
acid residues in DLC8 that make
key contacts with the peptides are
also shown in the Figure. Due to
its irregular strand structure, the b0
strand of DLC8 is also shown
using explicit atom representations
(yellow). (b) The distance between
the oxygen atom of the Thr4
hydroxyl group of the nNOS pep-
tide and the N
e
of His68 is also
indicated. (c) Schematic showing
the b-strand pairing between the b2
strand of DLC8 and the b strand of
the nNOS peptide and the Bim
peptide. The amino acid residues
that adopt b-strand structure are
highlighted by arrows. The amino
acid residues in the b-strands with
their side-chains pointing to the
dimer interface are shaded.
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