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Figure 3.
Figure 3 Schematic representation of TRY-N. Secondary-structure
elements forming the N-terminal domain are marked A1-F1 and the
C-terminal domain A2-F2 as defined previously (Rypniewski,
Mangani et al., 1995[Rypniewski, W. R., Mangani, S., Bruni, B.,
Orioli, P. L., Casati, M. & Wilson, K. S. (1995). J. Mol. Biol.
251, 282-296.]). The active site is indicated by the side chains
of the `catalytic triad': Ser195, His57 and Asp102. The side
chain of Asp189 is also shown at the bottom of the `specificity
pocket' defining the tryptic substrate specificity. The peptide
bound in sites S1 to S3 is indicated by a ball-and-stick model
with dark bonds.
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