|
Figure 3.
Figure 3: Overall architecture of the FGF1-FGFR2-heparin
complex. a, Electrostatic potential of the heparin-binding
site in the FGF1-FGFR2-heparin complex, mapped onto a molecular
surface rendition of the complex. The heparin is shown as a
stick model. In the ternary complex, the heparin decasaccharide
is surrounded by regions of positive charge (blue represents
+20e per Å 2). b, Superposition of heparin-linked FGF1 dimers.
The dimer from the FGF1-FGFR2-heparin complex is yellow, the PDB
entry 2AXM is blue. The FGFR2 ectodomains are shown in CPK
representation.
|
