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Figure 3.
Figure 3 Ribbon diagrams for PTB-34 and Sex-lethal. (A)
Comparison of tandem domain structures of PTB and Sex-lethal.
The relative orientation of the two domains shown for PTB is
arbitrary, as is the structure of the inter-domain linker. The
structure of Sex-lethal was solved crystallographically in the
presence of bound RNA (Handa et al., 1999), which has been
omitted from the figure. (B) Comparison of RRM-3 and RRM-4
domains from PTB with RRM-1 of Sex-lethal. PTB RRM-3 contains an
additional strand (  5)
on one side of the RNA binding surface. Note that the
conformation shown for the 4–
5
loop is only one of many conformations that are consistent with
the data (see Figure 2).
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