Figure 3.
Figure 3. Solution structure of the C[2]B domain. a, Backbone
superposition of the 20 simulated annealing structures of the
C[2]B domain (residues 541 -677). N and C indicate the amino and
carboxy termini, respectively. The numbers indicate the
positions of several residues to help identify the orientation
of the molecule. b, Superposition of the 20 structures showing
only the heavy atoms of side chains in a slice of 12 Å within
the centre of the domain. c, Ribbon diagram of the C[2]B domain
in the same orientation as a and b. The -strands
have been labelled 1 -8 and the positions of the two helices and
the Ca^2+-binding region (loops 1 -3) have also been indicated.
d, Ribbon diagram of the C[2]B domain in an orientation
approximately perpendicular to that of c, which shows how helix
2 runs parallel between the two -sheets.
The ribbon diagrams were prepared with the program Molscript49.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Cell Biol
(1999,
1,
106-112)
copyright 1999.
-strands
have been labelled 1 -8 and the positions of the two helices and
the Ca^2+-binding region (loops 1 -3) have also been indicated.
d, Ribbon diagram of the C[2]B domain in an orientation
approximately perpendicular to that of c, which shows how helix
2 runs parallel between the two