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Figure 3.
Figure 3. Electrostatic potential surfaces of the CaM−target
peptide complexes. In the upper panels, the surface of Ca ^2+
/CaM is shown with the target peptide as an yellow tube. The
peptide surface is in the lower panels. The surface is colored
according to the local electrostatic potential, with blue and
red representing positive and negative potential, respectively.
Acidic and basic residues interacting with the target peptide
are labeled in red and blue, respectively. a, CaM−CaMKK; b,
CaM−MLCK^19, ^20; c, CaM−CaMKII^21. The domain linker of CaM
in the CaM−CaMKII complex was modeled in the Insight II, since
residues 74−83 are absent from the PDB file because of the
high flexibility of this region.
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