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Figure 2.
Fig. 2. A, comparison of the overall bound conformations
of the cmFEEI inhibitor (in cyan for carbon atoms) and the pYEEI
inhibitor (in white for carbon atoms). The oxygen atoms are
shown in red, nitrogen is in blue, and phosphorus is in yellow.
Note the remarkable similarity for the Ile residue at the pY+3
position. B, close-up of the conformational overlap of the cmF
and the Tyr(P) residues, showing the translation of the phenyl
ring in the cmF inhibitor. The oxygen atoms on the phosphate
group are numbered. C, same as B, viewed 90 ° away around
the horizontal axis, showing the rotation of the phenyl ring in
the cmF inhibitor.
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