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Figure 2.
Figure 2. Superposition of Variable Domains and Overlay of
Complexed Peptides(A) Variable domain superposition. Residues
from conserved β regions of V[L] (4–6, 20–25, 33–38,
45–48, 63–65, 70–74, 86–89, 102–104) were superimposed
to visualize the V[L]/V[H] rearrangements. The Cα framework
atoms are oriented with V[L] at the left. Peptides are omitted.
Uncomplexed CB4-1, black; complexed with e-pep, yellow; h-pep,
red; u-pep, purple; d-pep, green.(B) Peptide overlay.
Superposition of V[L] and V[H] domains was performed as
described in Table 2. Only the peptides are displayed: e-pep,
yellow; h-pep, red; u-pep, purple; d-pep, green (N terminus:
right). For a general overview of the peptides in complex with
CB4-1 Fab, see Figure 4 in [27].
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