Figure 2.
Figure 2 Protein -DNA contacts. (A) A schematic view with
ribbons drawn through the C s
of the Tc3A DNA-binding domain (yellow) and through the
phosphate backbone of the DNA strands (blue and magenta). (B)
Sketch summarizing the hydrogen bonding (indicated by green
dotted lines, base-specific H-bonds by green solid lines) and
salt bridging contacts (blue lines) between the Tc3A domain and
the DNA. Gray boxes indicate residues involved in base-specific
contacts. Hydrogen bonds are at a maximum distance of 3.5 Å and
salt bridges at a maximum of 4.0 Å (Barlow and Thorton, 1983).
(C) and (D) Stereo views (Kraulis, 1991) of the HTH DNA contacts
in the major groove, and the N-terminus of Tc3A bound in the
minor groove of DNA, respectively. Hydrogen bonds are indicated
with green dotted lines.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(1997,
16,
6044-6054)
copyright 1997.
s
of the Tc3A DNA-binding domain (yellow) and through the
phosphate backbone of the DNA strands (blue and magenta). (B)
Sketch summarizing the hydrogen bonding (indicated by green
dotted lines, base-specific H-bonds by green solid lines) and
salt bridging contacts (blue lines) between the Tc3A domain and
the DNA. Gray boxes indicate residues involved in base-specific
contacts. Hydrogen bonds are at a maximum distance of 3.5 Å and
salt bridges at a maximum of 4.0 Å (Barlow and Thorton, 1983).
(C) and (D) Stereo views (Kraulis, 1991) of the HTH DNA contacts
in the major groove, and the N-terminus of Tc3A bound in the
minor groove of DNA, respectively. Hydrogen bonds are indicated
with green dotted lines.