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Figure 2.
Fig. 2. Energy-minimized atomic model of a substrate
hexapeptide, Asp-Ala-Asp-Glu-Tyr(P)-Leu, bound to the Yersinia
PTPase. The molecular surface of the protein atoms from the
PTPase-WO[4] crystal structure is shown in cyan. This surface
has been sliced (dark blue surface) to reveal a deep active site
pocket into which a model of a substrate hexapeptide was
manually docked and subsequently energy minimized. The
hexapeptide carbon, nitrogen, oxygen, and phosphorus atoms are
shown in yellow, blue, red, and yellow, respectively. The
peptide substrate runs from N terminus on the left of the figure
to C terminus on the right.
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