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Figure 2.
Interface between VEGF-C and VEGFR-2. (A) VEGF-C binding
interface on VEGFR-2. VEGFR-2 is shown as a cartoon
representation with the VEGF-C binding key residues highlighted
in sticks and labeled. (B) An overview of the VEGF-C/VEGFR-2D23
site 1 interface, with VEGF-C monomer A colored in green and
VEGF-C residues at the interface labeled. VEGFR-2 charge
distribution shown as a surface potential model. (C) The same as
in (B) for the site 2 interface with VEGF-C monomer B in orange
and the monomer 2 key residues labeled. (D) VEGF-C Asp123
interactions with VEGFR-2. Hydrogen bonds and salt bridges are
shown in gray dashed lines. (E) VEGF-C Glu169 interactions with
VEGFR-2 as in (D). (F) VEGF-C Thr148 and Asn149 interactions
with VEGFR-2 as in (D).
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