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Figure 2.
Ribbon drawing of the three MV-H–CD46 interacting regions
described in Figure 1b. CD46 and MV-H are shown in blue and
orange, respectively. Buried residues participating in critical
contacts are depicted in stick representation and labeled in the
three panels, with oxygens and nitrogens shown in red and blue,
respectively. Side chains of MV-H residues engaged in hydrogen
bonds (black dashed lines) with CD46 are highlighted in magenta,
whereas cysteines are yellow. (a) Contact region 1, showing
relevant contacts between MV-H and CD46 residues at the D′D
loop of SCR1 (Ile37–Leu40). Loops connecting the β-strands s2
and s3 (s2-s3) of blade β4 and the blades β4 and β5 (β4-β5)
are marked. (b) Contact region 2, showing interactions of MV-H
with the CD46 SCR1-SCR2 interdomain region. This surface
includes contacts between MV-H and CD46 residues linking Cys60
in SCR1 and Cys65 in SCR2, as well as the DE loop of SCR2. (c)
Contact region 3, showing interactions between MV-H and the SCR2
of CD46. The N-acetylglucosamine (NAG) residue attached to Asn80
of CD46 is shown in stick representation with carbons colored
green. Additional contacts are listed in Supplementary Table 1.
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