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Figure 2.
Figure 2. The Major Pol γ Subunit Interfaces
(A–C)
Pol γA- Pol γB proximal monomer interactions. The distal
monomer is omitted for clarity.
(A) Charge-charge
interactions between the thumb domain of Pol γA and the
C-terminal domain of Pol γB.
(B) L-shaped support between
Pol γA and the proximal monomer of Pol γB.
(C)
Hydrophobic interactions between the L helix of Pol γA and a
hydrophobic core of Pol γB. Mutated residues L^549, L^552, and
K^553 are shown.
(D) Sequence alignments of residues
involved in hydrophobic interactions between Pol γA and Pol
γB.
(E–G) Pol γA- Pol γB distal monomer interactions.
The proximal monomer is omitted for clarity.
(E) The
salt-bridge (2.8 Å) between Pol γA R^232 and the distal
Pol γB E^394.
(F) Pol γA-Pol γB distal monomer.
(G)
The weak van der Waals interaction (5.3 Å) between Pol γA
and the distal Pol γB monomer.
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