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Figure 2.
X-ray crystal structure of the LT1009 Fab:S1P complex. (A) A
ribbon diagram representation of the antibody Fab fragment. The
light chain is colored gold and the heavy chain is brown. S1P is
depicted as a ball-and-stick model with cpk coloring and the 2
Ca^2+ ions are represented as light gray spheres. (B) Close-up
view of the S1P binding site. Electron density from a 2 F[O] -
F[C] refined map contoured at 1.1 σ is displayed for the region
of the model within 1.9 Å of each atom in S1P. (C) A
semitransparent surface representation of the Fab reveals the
extent to which S1P, represented as cpk spheres, is buried upon
binding to LT1009.
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