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Figure 2.
The nSH2 domain of p85α forms a scaffold for the PI3Kα
enzyme. (A) p85α nSH2 acts as a scaffold and interacts with the
p85α iSH2 domain as well as the p110α kinase, helical, and C2
domains. (B) The nSH2 αA helix fits into a crevice between the
C2 and kinase domains. (C) nSH2 interactions with the p110α C2
domain. (D) Residue-residue interactions between nSH2 and the
helical and kinase domains.
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