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Figure 2.
Fig. 2. The chemical structures of tiamulin,
homoharringtonine, and bruceantin and the corresponding
difference electron density. Panels (a)–(c) show the chemical
structures of these inhibitors. Panels (d)–(f) show the
feature in the appropriate (F[o] − F[o]) difference electron
density map that was assigned to the three drugs, with the
structures of the drugs superimposed on them. Difference
electron density maps were contoured at 3σ. Residues forming
the A-site cleft are shown in cyan, and 23S rRNA bases are
numbered to correspond with the 23S rRNA of E. coli.
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