Figure 2.
A, molecular surface of the PYK2 in the active site region in
complex with ATPĪ³S (magenta). Critical side chains are labeled
(ball and stick representation) with hydrogen bonds (dashed
lines). B, active site of PYK2 bound to PF-431396 (magenta).
Hydrophobic residues interacting with the sulfonamide group are
shown in yellow.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2009,
284,
13193-13201)
copyright 2009.
