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Figure 2.
Comparison of the structures of monomeric CDK2, CDK4/cyclin
D3, and T160pCDK2/cyclin A. The 3 structures are viewed looking
down onto the CDK C-terminal domain from the N-terminal domain
and are colored according to the scheme used in Fig. 1. (A)
Monomeric CDK2. (B) CDK4/cyclin D3. (C) T160pCDK2/cyclin A. The
figure highlights the displacement of the CDK4/cyclin D3
activation segment away from the active conformation present in
T160pCDK2/cyclin A and its similarity to the structure of the
activation segment in monomeric CDK2 (monomeric T160pCDK2 PDB ID
code 1HCK).
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