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Figure 2.
Figure 2. Stereodiagram view of the superposition of 1SEM
(green), 1ZLM (magenta) and our OSF-SH3 (slate blue) with (A)
the conserved residues of OSF-SH3 for peptide binding were
labeled and shown in stick, and (B) the binding pocket of
peptide residue arginine. Arg26 and Glu30 of OSF-SH3 domain were
labeled and shown in stick view. Ligand peptide Ace-PPPVPPR
(red) of 1SEM was shown in line view in (A) and in stick view in
(B). (C) The putative binding interface of OSF ankyrin repeats.
Left: Electrostatic potential distribution on the potential
binding surface of OSF ankyrin repeats. Right: Stick view of
residues comprising the putative binding surface at the same
orientation.
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