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Figure 2.
Fig. 2. (a) Superposition of the Der f 1 (green) and Der p 1
(yellow) active sites. Interactions between residues are marked
with dashed lines, and interatomic distances (see Table 1) are
in Å. (b) Superposition of the putative Der f 1 metal
binding site (green) with the metal binding site observed in the
proDer p 1 (blue; PDB code 1XKG) and mature Der p 1 (yellow)
structures. Residues are numbered according to the Der f 1
sequence. The water molecules coordinating Y^3+ (cyan sphere)
were omitted for the sake of picture clarity. Coordination of
Ca^2+ (black sphere) in the Der p 1 structure (PDB code 3F5V) is
shown using dashed lines. (c) Water molecules (red spheres)
conserved in the Der f 1 (PDB code 3D6S), proDer p 1 (PDB code
1XKG) and mature Der p 1 (PDB code 3F5V) crystal structures.
Black sphere shows the position of the metal ion in the
structure of Der p 1.
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