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Figure 2.
The structures of DNA pol ι·N^2-ethyl-Gua Complexes
with incoming dCTP or dTTP. A, the structure of DNA pol ι
containing N^2-ethyl-Gua and incoming dCTP shows the
N^2-ethyl-Gua base rotated into the syn configuration. B, the
structure of DNA pol ι containing N^2-ethyl-Gua and incoming
dTTP shows the N^2-ethyl-Gua base in the anti configuration and
the N^2-adduct protruding into the minor groove. C, electron
density around the N^2-ethyl adduct and incoming dCTP. D,
electron density around the N^2-ethyl adduct and the γ
phosphate of the incoming dTTP.
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