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Figure 2.
Figure 2. Comparison of Ca^2+-Free and Ca^2+-Bound Forms and
Zn^2+-Bound Form of ALG-2
(A–C) Structures of EF1 (A),
EF3 (B), and EF5 (C) of Ca^2+-free form (cyan) and Ca^2+-bound
form (magenta) of des3-20ALG-2 and Zn^2+-bound form (green) of
full-length ALG-2 are superimposed and shown in ribbon
representation in side views and top views by aligning helices
of (A) α1 (E1), (B) α4 (E3), and (C) α7 (E5), respectively,
with the secondary structure matching program in COOT. Calcium
atoms and zinc atoms are shown as yellow spheres and gray
spheres, respectively.
(D) Overall structures of dimeric
ALG-2 molecules in the three forms are aligned at α7 of
molecule A and shown in wire presentation. The N-terminal
Gly/Pro-rich region is invisible.
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