|
Figure 2.
Figure 2. Ca^2+/CaM-Ca[V]2 Interaction Details
(A)
Ca[V]2.3 Ca^2+/N-lobe.
(B) Ca[V]2.2 Ca^2+/N-lobe.
(C)
Ca[V]2.3 Ca^2+/C-lobe.
(D) Ca[V]2.2 Ca^2+/C-lobe.The IQ
domain as shown in stick representation with major anchor
positions colored white. As Ca[V]2.1 and Ca[V]2.3 structures are
equivalent and the Ca[V]2.3 structure is higher resolution, we
only show Ca[V]2.3 here. Ca^2+/CaM lobes are shown in surface
representation. Residues contributing to hydrophobic (yellow),
negatively charged (red), positively charged (blue), and polar
(green) interactions (≤4 Å) to the IQ domain indicated.
Labels for IQ domain residues are boxed.
(E) Diagram of the
major Ca[V]1 and Ca[V]2 IQ domain anchor positions. The
isoleucine of the IQ motif is labeled as position 0. Ca[V]2.1,
Ca[V]2.2, and Ca[V]2.3 major anchors are shown by yellow,
purple, and orange ovals, respectively. Ca[V]1.2 anchor
positions are shown by red squares.
|
