|
Figure 2.
Crystal structure of WDR5 bound to MLL1 peptide. A, top and
side views of WDR5 bound to MLL1 peptide. The MLL1 peptide is
bound to a pocket located at the center of WD40 β-propeller
structure, previously shown to be a histone H3-binding pocket.
B, F[o]-F[c] map (shown in 3σ) between a refined free WDR5 and
data collected from the WDR5-MLLpeptide complex. C,
superimposition between WDR5-MLL peptide (blue-green) and
WDR5-H3 (yellow-red) complex structures. D, the electrostatic
surface potential representations of WDR5-MLL1pep and
WDR5-H3K4me2 complex structures. MLL1 peptide and H3K4me2
peptide utilize distinct pockets for binding.
|
