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Figure 2.
Figure 2. OSR1 active conformation and conformational change
induced by RFXV peptide binding. (A) OSR1 activation segment
with the secondary structure elements and the residues discussed
in the text represented as cartoon and sticks, respectively,
colored in blue and red (  -strands
and  -helices).
Shown in sticks are Lys46, Glu63, and Arg145. (B) CDK2
activation segment with the secondary structure elements and the
residues discussed in the text represented as cartoon and
sticks, respectively, colored in blue and red ( -strands
and -helices).
Shown in sticks are Lys33, Glu51, and Arg126. (C) Model of the
active conformation of the OSR1 kinase domain with the
activation segment and -helix
C represented as cartoon. Shown in sticks are Lys46, Glu63,
Arg145, Arg183, and Thr185. (D) Distance-distribution function
are for the OSR1(1-527) protein and for OSR1(1-527)-RFXV peptide
complex as determined by SAXS. Radius of gyration and D[max] are
also indicated. Vector length is shown as Å and p(r) as
arbitrary unit.
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