Figure 2 - full size

Figure 2. Figure 2: Intermolecular hydrogen-bonding alignments in the T. thermophilus Ago bound to a 21-base DNA guide strand. a, Insertion of the 5'-phosphate of the DNA guide strand into the binding pocket in the Mid domain. b, Positioning of stacked 3'-end residues 20 and 21 of the DNA guide strand into the binding pocket in the PAZ domain. c, Positioning of stacked residues 2 to 6 of the DNA guide strand, with emphasis on intermolecular interactions. d, Positioning of stacked residues 6 to 10 and 11 of the DNA guide strand, with emphasis on intermolecular interactions.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nature (2008, 456, 209-213) copyright 2008.