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Figure 2.
Fig. 2. (a) Superposition of the NCAM2 Ig1 (blue) and NCAM
Ig1^5 (yellow) domains shown in stereo view. The β-strands are
labelled as in Fig. 1a; residues in the NCAM2 hinge region and
residues around the NCAM β-bulge that separates the A/A'
β-strands are numbered. The absence of proline and glycine from
NCAM2 Ig1 at positions 7 and 10, respectively, may reduce
β-bulge stability and contribute to the domain swapping
observed for the NCAM2 Ig1 domain. (b) Superposition of the
domain-swapped dimer of NCAM2 Ig1 (blue/grey) and the
domain-swapped dimer of E-cadherin EC1 (yellow/magenta). Despite
the differences between cadherin and Ig domains, the similarity
between the domain-swapped dimers is clearly visible.
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