|
Figure 2.
Figure 2. Overall Structure of EphA3 Kinase
All
molecular graphics figures were generated using PyMOL unless
noted.
(A) Cartoon representation of the EphA3 JMKIN base
ANP structure. The structure is shown in forest green and in
cartoon representation. Secondary structure elements and regions
discussed in the test are labeled. Regions of disorder are
indicated with dashed lines. This structure was chosen because
it represents the highest degree of order modeled for all the
EphA3 structures.
(B) Ribbon representation of JMKIN base
ANP overlaid with EphB2 in pink (1JPA). Alignment over all atoms
yields an rmsd of less than 1Å for all structures; key
regions of structural difference occur in the N-terminal lobe,
centered on the JMS and the AL, along with slight differences in
the β1-G loop-β2 region.
|
