Figure 2 - full size

 

Figure 2.
(a) Packing of the MG8 (green) and the C5d (gray) domains in C5 around Ser1007 and Ala1010. (b) The region in a at the thioester (TE) formed by Cys1009 and Gln1012 in bovine C3 (orange) superimposed onto the C5d domain of C5 (green and gray, as in a). (c) The thioester formed by Cys838 and Gln841 in TEP (light blue) and in C5 (green and gray). In b and c, the catalytic histidine residues 1125 and 951 are in the foreground.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Immunol (2008, 9, 753-760) copyright 2008.