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Figure 2.
Figure 2. Crystal Structure of the CaM-NR1C1p Complex
(A) NR1C1p sequence and structure superimposed on its electron
density map contoured at 1.0σ.
(B and C) Alternate views
of CaM-NR1C1p (2HQW) showing the CaM N-domain backbone (blue),
the C domain (red), Ca^2+ ions and binding sites (yellow), and
NR1C1p (gray). The figure was made with MacPymol.
(D and E)
Alignment of 17 canonical CaM-target complexes by their Cα
atoms of the (D) N-domain (residues 5–72; 68 atoms) and (E)
C-domain (residues 84–146; 63 atoms) FLMM residues as
described in Experimental Procedures.
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