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Figure 2.
FIGURE 2. The S1 ligand binding site in M-ficolin, TL5A,
and L-ficolin. A–C, detailed views of the interactions of
GalNAc, GlcNAc, and Neu5Ac in site S1 of M-ficolin. D,
superposition of the ligand-free and three ligand-bound
structures of M-ficolin showing that Tyr^271 is the only mobile
component in site S1. E, interaction of GlcNAc in the homologous
S1 binding site of tachylectin 5A (14). F, superposition of the
S1 binding sites of M-ficolin (magenta) and L-ficolin (green).
In L-ficolin, steric hindrance (as shown by black lines)
prevents accommodation of large ligands such as Neu5Ac.
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