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Figure 2.
Figure 2. Structural features of the core domain of ST. (a)
Sequence alignment of ST from SV40 and ST and MT from
polyomavirus. Yellow, conserved residues; red, zinc-binding
residues; blue squares and magenta triangles, residues that
interact with the A subunit of PP2A through hydrogen bonds and
van der Waals contacts, respectively; purple asterisks, residues
whose mutation abrogates interaction with the A subunit^18, ^35.
(b) Superposition showing structural similarity between
zinc-binding motifs 1 and 2 in ST (colored yellow and orange,
respectively).
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