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Figure 2.
Figure 2. Interdomain interactions in CRKII and pCRKII[1–228].
(a) Ribbon model of hydrophobic core of CRKII, between the
ISC and the SH domains, colored as in Figure 1. Side chains of
hydrophobic core are shown as sticks. (b) Interaction surfaces
between SH2 and nSH3 in CRKII (left), and between the C3G
peptide and nSH3 in CRKII (right). (c) Electrostatic surface
potential (blue, positive; red, negative) of SH2 in
pCRKII[1–228] and its recognition of 221-pYAQP-224 (shown as
stick model). (d) Electrostatic surface potential of nSH3 in
pCRKII[1–228] and its recognition of the inter-SH2-SH3 region
(stick model).
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