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Figure 2.
Figure 2. Hydrophobic and Electrostatic Contacts in the Kv7.4
Coiled-Coil Domain
(A) Hydrophobic layers of the
coiled-coil core. Van der Waals spheres depicting the side
chains of the “a” (blue) and “d” (pink) layers on a
ribbon backbone (gray) are shown. The N- and C-terminal ends of
the coiled coil are indicated.
(B) Geometry of
individual coiled-coil “a” and “d” layers. Top
pictograms represent “a” (right) and “d” layers (left).
Arrows show the direction from the N to C terminus, open circles
represent the C[α] atoms, and black circles the C[β] atoms.
Ball-and-stick representations show each layer of the core. Van
der Waals spheres indicate core residues, colored as in (A).
(C) Intra- and intermolecular electrostatic interactions.
Ribbon diagram of tetramer with helices colored as in Figure 1D
shows network 1 and network 2 interactions between the side
chains (shown as sticks) of the green and orange subunits. Salt
bridges (black lines) and hydrogen bonds (dotted lines) are
indicated. Side chain labels are color coded to indicate the
subunit of origin.
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