Figure 2.
Figure 2: ModB architecture and conserved gate regions. a,
View from the extracellular side onto the transmembrane ModB
subunits, with one subunit in yellow ribbon representation, the
other as a blue backbone trace. Helices are numbered as in b,
and conserved motifs forming the closed external gate are
coloured green and red in both subunits. Relevant C positions
are depicted as black spheres, with their residue numbers
indicated. The conserved Phe 200 is shown in ball-and-stick
representation. b, Topological scheme of the ModB subunit.
Transmembrane helices are numbered consecutively, and short
helices following a transmembrane helix additionally carry
letters. The conserved gate regions are coloured as in a. c,
Alignment of the A. fulgidus ModB sequence with those of other
molybdate and sulphate ABC transporters (abbreviated species
name is followed by an underscore and the ABC transporter name).
Residues with significant conservation are shaded grey. Helices
and conserved motifs are indicated above the sequences.
Conserved gate regions are coloured as in a. TM, transmembrane.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2007,
446,
213-216)
copyright 2007.
positions
are depicted as black spheres, with their residue numbers
indicated. The conserved Phe 200 is shown in ball-and-stick
representation. b, Topological scheme of the ModB subunit.
Transmembrane helices are numbered consecutively, and short
helices following a transmembrane helix additionally carry
letters. The conserved gate regions are coloured as in a. c,
Alignment of the A. fulgidus ModB sequence with those of other
molybdate and sulphate ABC transporters (abbreviated species
name is followed by an underscore and the ABC transporter name).
Residues with significant conservation are shaded grey. Helices
and conserved motifs are indicated above the sequences.
Conserved gate regions are coloured as in a. TM, transmembrane.