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Figure 2.
Figure 2: Conformational states of gp120. The unliganded,
b12- and CD4-bound conformations of gp120 are depicted, with
polypeptide in ribbon representation and disordered regions as
dashed lines. Inner domains are grey, outer domains are red and
regions that in the CD4-bound state correspond to the bridging
sheet are blue. Both b12- and CD4-bound conformations are of the
Ds12 F123 variant of HIV-1, whereas the unliganded structure is
of simian immunodeficiency virus (SIV). Comparison of these
three gp120 conformations highlights not only the structural
plasticity of the inner domain and bridging sheet, but also the
conformational stability of the outer domain.
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